BioNumerics is a bioinformatics desktop software application that manages microbiological data.

PulseNet, a network run by the Centers for Disease Control and Prevention (CDC), uses BioNumerics to compare pulsed field gel electrophoresis (PFGE) patterns and whole genome sequences from different bacterial strains.

[1][2] CaliciNet, an outbreak surveillance network for noroviruses, is another example of a network which uses BioNumerics to submit norovirus sequences and basic epidemiologic information to a central database.

The entries correspond to the individual organisms or samples under study and are characterized by a unique key and by a number of user-defined information fields.

Examples of BioNumerics applications are whole genome Multi Locus Sequence Typing (wgMLST), whole genome Single Nucleotide Polymorphisms (wgSNP), genome comparison, identification based on MALDI-TOF Mass Spectrometry, PFGE typing, Amplified Fragment Length Polymorphism (AFLP) typing, sequence-based typing of viruses, antibiotic resistance profiling and functional genotyping.