The school was opened August 21, 1952 and named in honor of Edward Dominic Fenwick, a Dominican friar and first Roman Catholic Bishop of Cincinnati.

Due to outgrowing the original site, the school moved on November 20, 1962 to Manchester Road in Middletown.

The growth continued and in September 2004 the school moved to a new campus, on State Road 122 on the east side of Middletown.

Fenwick offers many clubs including: [3] Fenwick's sports teams are sanctioned by the Ohio High School Athletic Association.

The boys teams compete in the Greater Catholic League.