It flows from the city of Vaughan in the Regional Municipality of York to the Humber River in Toronto.

It passes the main York University campus and heads into the Downsview area in a forested ravine.

South of Weston Road, Black Creek runs in a man-made concrete channel in the median of Humber Boulevard, continuing to the south of Alliance Avenue and through Lambton Golf Club, and reaches its mouth as a left tributary of the Humber River near Scarlett Road and Dundas Street West at an elevation of 89 metres (292 ft).

[1][2][4][3] The environmental health of Black Creek and its watershed has been an important issue in Toronto and the GTA for decades.

The creek can be split into 3 general zones: source-Highway 407, Highway 407-Weston Road, and Weston Road-Humber River.