Players assume control of the Penitent One, a silent knight who must embark on a new adventure in a new kingdom to prevent the rebirth of a curse named "The Miracle".
The weapons in the game include the Veredicto, a war censer with the farthest reach that deals powerful but slow attacks and is incapable of parrying; Sarmiento and Centella, a dual-wielding rapier and dagger with fast and rapid strikes but has the shortest range and a damage bonus that is lost if the player gets hit; and the Ruego Al Alba, a praying blade with balanced attributes.
Afterwards, Crisanta attempted to put a stop to the Miracle's plans by slaying the child before it could be born, but she was thwarted and killed by Eviterno.
What resulted was a miraculous immaculate conception, but the birth instead created the disfigured Witness and released a plague that killed the wife and many others.
The Penitent One eventually defeats the Incarnate Devotion, leading to one of two endings: Shortly after defeating all of the archconfraternity members and before the final confrontation with the Incarnate, the Penitent One has been called by Crisanta's soul to restore the original Mea Culpa sword which was destroyed after the High Wills' death in order to end the Miracle's threat for good.
She gives him the Mea Culpa's hilt, but he is ambushed by another penitent named Brother Asterion, who serves the Miracle through his unnamed master.
Upon defeating the Incarnate Devotion with the Mea Culpa, Crisanta's soul claims the blade and delivers the final blow, ending the Miracle's reign and allowing her to ascend to the afterlife.
According to producer David Erosa, an important goal for the team was to make the game "closer to the classic Metroidvania genre".
Therefore, the team worked to expand the Penitent One's arsenal of weapons, providing him with more means to combat enemies and traverse the world.
[9] Like the original game, the team took inspirations from paintings and local Spanish culture, history and architecture while creating Blasphemous 2.