Bloor Street runs from the Prince Edward Viaduct, which spans the Don River Valley, westward into Mississauga where it ends at Central Parkway.

A small footpath from Howard Street was the only means to reach the eastern end of the valley to continue along Danforth Avenue until the Prince Edward Viaduct was completed in 1918.

[8] Bloor street begins at the eastern edge of the Prince Edward Viaduct, which crosses the deep and wide valley of the Don River.

Rents on the upscale Bloor Street have doubled in 4 years, ranking as the 22nd most expensive retail location in the world in 2006, up two spots from 2005.

[citation needed] Under the intersection of Yonge and Bloor Streets is the Bloor–Yonge subway station, which is the busiest in the city, serving approximately 368,800 people a day.

The stretch of Bloor between Yonge and Avenue Road, in Yorkville, is called Mink Mile, and it is the most prestigious shopping street in Toronto.

West of the university, which extends to Spadina Avenue, Bloor Street runs through a diverse series of neighbourhoods such as The Annex, Koreatown, Dufferin Grove, Brockton, Roncesvalles, High Park and Runnymede.

Construction began in 2019 by the City of Toronto to reconfigure the interchange at Kipling Avenue and Dundas Street into an at-grade intersection.

This removed the "Spaghetti Junction" created in 1961 and renamed Dunbloor Road as Dundas Street to reconnect the broken sections.

[10] On May 4, 2016, city council voted 38-3 to implement physically separated bike lanes along a 2.6 km (1.6 mi) stretch of the street.