Farther north, with the exception of the section through Simcoe County, where it forms the 8th Concession, it is the meridian for the rural municipalities it passes through.

In Dufferin County, for instance, parallel roads are labelled as EHS or WHS for East (or West) of Hurontario Street.

However, most of the street was alternately named Centre Road, due to its role as a divider for much of its length,[1] and still is today in parts.

Some businesses use the number in their names, and even the Ministry of Transportation's traffic camera website continues to identify the street as "Hwy 10",[3] as does some signage at the Hurontario & 407 Park and Ride lot and transit terminal.

Hurontario Street was created in 1818 by incorporating the combination of the 8th Concession leading south from the harbour on Georgian Bay that later became the site of Collingwood, and the southern part of the Toronto-Sydenham Road, which ran between Toronto Township and Sydenham (present and former Highway 10 between what is today Mississauga and Owen Sound), effectively creating a branched interlake route.

During the construction of the interchange with the Highway 410 extension and Valleywood Boulevard, Hurontario Street was temporarily diverted between August 2007 and November 16, 2009, onto an alternative alignment.

At Burnhamthorpe Road, Hurontario passes through Mississauga's City Centre, with the Absolute World condominium towers rising at the northeast corner.

After crossing Highway 403, it passes by more high-rise condominiums and suburban mid-density development until it approaches Matheson Boulevard, where a preserved historic farmstead, the Britannia Farm, operated by the Peel District School Board, is located.

North of Glen Huron, it becomes a major road again as it joins Simcoe County Road 124 (which, along with Highway 10, carries the Orangeville-Collingwood through traffic south of this point), until its terminus in Collingwood at Side Launch Way, one block north of First and Huron Streets (Highway 26).

The final block is a short one-way northbound extension built in 2009[8] to serve a residential redevelopment project on the site once occupied by the now-closed Collingwood Shipyards.

The MiWay express bus and the southern portion of Zűm are slated to be replaced by a light rail transit line, the Hurontario LRT, along the street in Mississauga and a short distance into Brampton.