Boca de Cupé is a corregimiento in Pinogana District, Darién Province, Panama with a population of 1,167 as of 2010.

[1] The town is not served by any paved roads, with the Pan-American Highway to the north ending at Yaviza.

Civilians are not permitted to travel farther east towards Colombia.

[2][3] In the early 1900s, a single-gage railway ran to the town from the Cana gold mines.

[5] Villages within the corregimiento farther up the river include Sobiaquirú.