The Tuira River is located in the Darién Province of eastern Panama.

It flows into the Bay of San Miguel at the province capital of La Palma.

It runs past villages as it flows downstream including Matuganti, Sobiaquirú, El Balsal, Boca de Cupe, Capetí, Yape, Aruza, Unión Chocó, Vista Alegre, and Pinogana.

[3] It meets the Chucunaque River at El Real de Santa María and then flows northwest towards La Palma.

[4] Via the Chucunaque, one can reach Yaviza, which is the terminus of the northern end of the Pan-American Highway.