The hospital was originally located on Church and Wood St. in downtown Norfolk in the home of the late Miss Ann Plume Behan Herron.

[1] When Herron died of yellow fever in 1855, being a wealthy patron, she willed the house to the sisters for the purpose of founding a hospital.

The Hospital of St. Vincent DePaul was incorporated in 1856 by eight Daughters of Charity during the yellow fever epidemic.

[5] In 1996, the Sisters of Bon Secours extended the Daughters of Charity ministry by assuming the sponsorship for DePaul.

On March 31, 2021, DePaul Medical Center was permanently closed to Acute care services.