Located in Norfolk, Virginia, in the Ghent neighborhood and adjacent to Downtown, the hospital serves as the Hampton Roads region's only Level I trauma center.

Together with the adjacent Children's Hospital of the King's Daughters, Eastern Virginia Medical School and the Norfolk Department of Health, the Eastern Virginia Medical Center is the largest conglomerate center for health in Hampton Roads.

In 1981 Elizabeth Carr was born at the hospital, becoming America's first in-vitro fertilization baby.

[7] The first heart transplant performed in Hampton Roads occurred at the hospital in 1989.

Britt returned to Hampton Roads and built a well–respected general surgery program and established Norfolk General Hospital as Hampton Roads' only Level 1 trauma center.