The Bonasila River (Deg Xinag: Ngidegh Srixno') is a 125-mile (201 km) tributary of the Yukon River in the U.S. state of Alaska.

[3] It heads in the Nulato Hills and flows generally southeast to the Bonasila Slough, an anabranch of the larger river.

[3] The slough flows around the west side of Elkhorn Island, which is about 27 miles (43 km) northwest of Holy Cross, further downstream on the Yukon.

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