Physician and botanist Ludwig Jungermann (1572–1653) laid out the garden over an area of 1200 m2.
The garden fell into decay during the Thirty Years' War (1618–1648), but in 1699 the construction of a coldhouse for frost-sensitive plants was recorded, and in 1720 its first glasshouse was built (subsequently demolished in 1859).
In 1805, when the city's fortress wall was torn down, the resultant space was incorporated into the garden; its remnants are still present under an artificial hill.
The garden was rearranged in 1891 to reflect a systematic organization, and in the early 1900s a large tropical house was constructed.
The tropical house was destroyed in World War II, and the garden itself severely damaged.