The Brady Street Bridge, also known as the South 22nd Street Bridge, was a steel bowstring arch bridge in Pittsburgh, Pennsylvania, which crossed over the Monongahela River at South 22nd Street.

Its main span was a tied arch with a suspended road deck, with two through-truss side spans, carrying two traffic lanes between Brady Street on the Pittsburgh side and South 22nd Street on the south side.

Approach viaducts were built at either end.

Over two years later on May 29, 1978, the old bridge span was blasted into the Monongahela River.

During the cleanup process that followed, railings from its remains were rescued by the Pittsburgh History and Landmarks Foundation and utilized in the construction of the Station Square station.