This large area of the frontal cortex is believed to play a role in planning complex, coordinated movements.

In the human brain, it is located on the portions of the precentral gyrus that are not occupied by Brodmann area 4; furthermore, BA6 extends onto the caudal portions of the superior frontal and middle frontal gyri.

It is bounded rostrally by the granular frontal region and caudally by the gigantopyramidal area 4 (Brodmann, 1909).

[1] Brodmann area 6 is a cytoarchitecturally defined portion of the frontal lobe of the guenon.

Distinctive features (Brodmann-1905): It is thick relative to other cortical areas; the transition from cortex to subcortical white matter is gradual; cell layers are indistinct; and the internal granular layer (IV) is absent.