Buseto Palizzolo (Sicilian: Palazzolu) is a town and comune in North-Western Sicily, Italy, administratively part of the province of Trapani.

Buseto Palizzolo is located in the hills east of Trapani, the highest of which is Monte Luziano [it] with a height of 500 metres above sea level.

Buseto Palizzolo is composed of various areas and hamlets, without a main central settlement.

These settlements blur into one another, but the frazioni of Bruca, Fazio, and Città Povera [it] are located at a distance of 11, 5, and 6 km respectively from the centre.

3 km southeast of Buseto Superiore is Bosco di Scorace [it], a vast wooded area which is among the largest in western Sicily.