Santa Ninfa is a town and comune in the province of Trapani, Sicily, southern Italy.

Santa Ninfa was founded in 1605 by Luigi Arias Giardina who, with approval of King Philip III of Spain, began to urbanize the country with roads and civil and religious buildings.

Santa Ninfa experienced a large emigration since the early 20th century: many inhabitants of the land left the country for the United States of America, Canada and Venezuela.

On January 15, 1968 the country of Santa Ninfa was hit by the disastrous earthquake of Belice.

The quake was of the 9th grade on the Mercalli's Intensity Scale, and caused collapses in the entire country.