Campobello di Mazara (Sicilian: Campubbeḍḍu) is a town in the province of Trapani, Sicily, southern Italy.

Its inhabitants are scattered in the town center and the minor seaside frazioni of Tre Fontane and Torretta Granitola, populated mostly during the summer period.

It borders on the neighbouring cities of Mazara del Vallo and Castelvetrano, and is colloquially known just as Campobello.

Near the town lies Rocche di Cusa, the ancient quarries from which the Selinuntines extracted stone to build temples.

Cultivated fields, mainly olive groves and vines, characterize the landscape of Campobello di Mazara.