The full name of the municipality was created in 1997 and is meant to highlight the presence within its territory of the 5th century BC Doric temple of Segesta, widely regarded as one of the most intact of its type.

Calatafimi's part of Sicily was one of the first to be occupied by the Aghlabids from Ifriqiya in their conquest of the island, and was one of the last centres of Islamic culture after the end of the Norman rule.

There are also references to an Islamic-period town called Calathamet (Qalʿat al-Ḥamma, قلعة الحمّة), on the border of the territories of Calatafimi and Castellammare del Golfo, possibly equating the modern Terme Segestane.

There are written documents about it only since the middle of the 12th century when Muhammad al-Idrisi, an Arab traveller and geographer, describes it as “an ancient and primitive with a populated village”.

In 1282, during the rebellion of the Sicilian Vespers, the Provençal feudal lord Gugliemo Porcelet lived in it; the rebels spared his life and he was sent back to Provence together with his family.

It is located in via Marconi, near the Town Hall: it was the house of the parish priest Don Antonino Pampalone (1810–1866), a fervent liberal and deputy for Calatafimi at the Sicilian Parliament of 1848.

Its origin dates back to the 12th century and is dedicated to Saint Sylvester the Pope, the oldest patron of Calatafimi who, according to the popular tradition, protected the town from the incursions of Muslims who rebelled against the imperial power.

As the primitive urban nucleus enlarged and the population increased, the original building was amplified and modified several times between the XV and the 18th century because it was too small to hold the believers.

Thanks to its width it was the place of popular assemblies, like the one in 1655 which led to the election of Maria Santissima di Giubino as the patroness of Calatafimi against the invasion of grasshoppers that were destroying crops.

The high altar is closed by a classical aedicula with a curvilinear tympanum, inserted in the group, with stuccoes and gilt decorations on the walls.

As it suffered considerable damages owing to the 1968 Belice earthquake, the present timber- trussed roof is due to a subsequent restoration.

Its fame is linked to the memory of the Blessed Archangel Placenza from Calatafimi, who lived here for some time, and to the devotion to the Most Holy Mary of Giubino, patroness of this town.

The façade has a stained-glass window with holy motifs and the main door is framed by Corinthian square pilasters, surmounted by a triangular pediment.

Religious events at Calatafimi-Segesta include: Paolo Mirabella (Melbourne, Australia) [4] The economy of Calatafimi is primarily agricultural, the most important crops being citrus, grapes and olives.