Butter Creek is a 57-mile (92 km) long creek in the U.S. state of Oregon.

The source of the creek is at an elevation of 5,034 feet (1,534 m) in Umatilla National Forest, while the mouth is at an elevation of 535 feet (163 m) upstream of Hermiston, Oregon.

Butter Creek has a 465-square-mile (1,200 km2) watershed, and is a tributary of the Umatilla River.

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