[9] CREM transcription factors also play an important role in many physiological systems, such as cardiac function,[10] circadian rhythms,[11] locomotion and spermatogenesis.

[12] This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters.

Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness.

[7] The chromosomal location of CREM gene is at 10p11.21, where it starts at 35415769 and ends at 35501886 bp from pter ( according to hg19-Feb_2009)[13] CAMP responsive element modulator has been shown to interact with FHL5.

[19] The results showed the first step in the process of sperm formation would be blocked if the germ cell development in mice CREM gene were disrupted.