[5] When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and interleukin 4 production.

Adipocyte-specific CD1d knock-out mice, when fed a high-fat diet, are protected from obesity and exhibit reduced adipose tissue inflammation.

[13] Research from 2004 showed that iNKT cell counts may be reduced in diabetes type II.

Transgenic non-obese mice in which CD1d molecules were overexpressed under the control of the insulin promoter within the pancreatic islets exhibited restored function of NKT cells as immunoregulatory.

One study showed that feeding CD1d knock-out mice a high-fat diet impaired lipid metabolism in the liver.