[5][6] The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.

Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains.

Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility.

CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins.

[17] This article incorporates text from the United States National Library of Medicine, which is in the public domain.