The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth, and motility.

[5] CD63 is a good marker for flow cytometric quantification of in vitro activated basophils for diagnosis of IgE-mediated allergy.

Initially, deletion and point mutants were used to investigate the role of the C-terminus, which contains a putative lysosomal-targeting/internalisation motif (GYEVM).

C-terminal mutants showed increased surface expression and decreased intracellular localisation relative to CD63Wt.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.