23554269831ENSG00000106025ENSMUSG00000029669O95859Q8BKT6NM_012338NM_173007NM_001363814NP_036470NP_766595NP_001350743Tetraspanin-12 (Tspan-12) also known as tetraspan NET-2 (NET2) or transmembrane 4 superfamily member 12 (TM4SF12) is a tetraspanin protein that in humans is encoded by the TSPAN12 gene.

It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.

Its main binding partner is the ADAM10 protein,[5] a sheddase that interacts with a variety of adhesion molecules that are found on the cell membrane including L1-CAM, E-Cadherin, N-Cadherin and CD44.

[6][7] It also binds to the MT1-MMP metalloprotease protein that is closely related to ADAM10 but has a minimal effect on promotion of expression and function.

[9] TSPAN12 is a significant contributor to primary and metastatic cancer and is responsible for protecting β-catenin from degradation.