[5][6] The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses.

Alternative splicing results in multiple transcript variants encoding the same protein.

[6] This article incorporates text from the United States National Library of Medicine, which is in the public domain.