CD82 (gene)

373212521ENSG00000085117ENSMUSG00000027215P27701P40237NM_001024844NM_002231NM_001271462NM_007656NP_001020015NP_002222NP_001258391NP_031682CD82 (Cluster of Differentiation 82), or KAI1, is a human protein encoded by the CD82 gene.

[5] This metastasis suppressor gene product is a membrane glycoprotein that is a member of the tetraspanin/transmembrane 4 superfamily.

Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter.

Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

[10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.