[5] CD48 is a member of the CD2 subfamily of the immunoglobulin superfamily (IgSF) which includes SLAM (signaling lymphocyte activation molecules) proteins, such as CD84, CD150, CD229 and CD244.

[6][7][8][12][13] Approximately 35-40% of the total molecular weight is attributed to the carbohydrate side chains.

[12] Like all other GPI anchor protein (GPI-AP), CD48 is deficient in erythrocytes (red blood cells).

Heterozygous germline mutation in a patient was associated with a recurrent inflammatory syndrome resembling hemophagocytic lymphohistiocytosis.

[23] This article incorporates text from the United States National Library of Medicine, which is in the public domain.