Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster.

Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia.

Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.

Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.

[8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.