Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body.

Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways.

This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption.

[6] Epigenetic regulation of Annexin A2 has been identified as a key determinant of mesenchymal transformation in brain tumors.

[7] Maternal deficiency of the ANXA2 gene contributes to shallow decidual invasion by placental cytotrophoblast cells.