[5][6] The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions.

The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.

[8] One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.

[9] Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.

[11] This article incorporates text from the United States National Library of Medicine, which is in the public domain.