C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization.

[6][7] C/EBPγ forms heterodimer with ATF4 for transcriptional activation of target genes in autophagy specifically to amino acid starvation.

[8] C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of chronic pain and mechanical hypersensitivity after some types of injury or surgery.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub.