1951107934ENSG00000008300ENSMUSG00000023473Q9NYQ7Q91ZI0NM_001407NM_080437NM_001359572NM_001359573NP_001398NP_536685NP_001346501NP_001346502Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

[5][6] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily.

The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins.

It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions.

[6] This article incorporates text from the United States National Library of Medicine, which is in the public domain.