[5][10] CHI St. Luke's Health has continued to expand, opening its seventh hospital campus in January 2016.

[11][12][1] St. Luke's began its partnership with Baylor College of Medicine in 1961 to serve as a teaching hospital for its medical students.

[18][14] CHI St. Luke’s has continued to strengthen its affiliation with Texas Heart Institute, investing to expand its research and education initiatives.

[24] The next year, Texas Heart Institute became the first to demonstrate that C-Reactive Protein (CRP) causes vascular inflammation.

[26] In 2003, Texas Heart Institute became the first nationally ranked cardiovascular center in the United States to open a cath lab medical simulation training center and performed the first implantation of a HeartMate II LVAD in the United States.

[27][28] The next year, they conducted the first FDA-approved clinical trial of adult stem cell therapy for congestive heart failure in the United States.

[34] That same year, Baylor St. Luke’s Medical Center became the first hospital in Texas to earn 3 Beacon Awards for Excellence from the AACN.

It has been ranked 24 years in a row among the nation’s top 10 Cardiology & Heart Surgery Centers by U.S. News & World Report.

"[43] In 2012, it became the second hospital in the state of Texas and the first in Houston to earn the International Organization for Standardization’s ISO 9001:2008 Quality Management System certification.

[48] In 2013, it was awarded the International Organization for Standardization’s ISO 9001:2008 Quality Management System certification and was distinguished as one of the 2013 top hospitals for surgery in Houston by Consumer Reports.

[49][50] In 2012, CHI St. Luke's Health–Sugar Land Hospital received the NRC Picker’s Path to Excellence Award.

[54] CHI St. Luke's Health–The Vintage Hospital's Women’s Services department received a “Distinguished Rating” by the TDSHS in 2013.

[57] It received the “Exemplary Five Star Service Award” in vital statistics registration by the TPHA for the 3rd year in a row in 2012.

[64] CHI St. Luke's Health comprises seven hospitals, three freestanding emergency centers, six medical groups, and four outpatient and specialty clinics.