It has a conserved calcium-binding EF hand domain, which consists of two alpha-helices connected by a loop.

It interacts with integrins, which are transmembrane receptors that play a key role in cell signaling and adhesion to the extracellular matrix.

[8] CIB1 is involved in several cellular processes that are important for cancer progression, including cell adhesion, migration, and invasion.

[8] The structure and function of CIB1 make it an important protein in regulating various cellular processes, including those involved in cancer progression, and targeting it may offer potential therapeutic benefits.

In breast cancer, CIB1 has been shown to promote cell proliferation, migration, invasion, and metastasis.

Studies in mice have shown that CIB1 deficiency leads to impaired sperm motility and reduced fertility.

Studies have shown that CIB1 is expressed in spermatogonia, spermatocytes, and spermatids, indicating its role throughout the entire process of spermatogenesis.

[8][15] In mice, CIB1 deficiency has been shown to lead to decreased spermatogonia proliferation and impaired differentiation into spermatocytes, resulting in reduced sperm production and male infertility.