2XZG, 4G55121367300ENSG00000141367ENSMUSG00000047126Q00610Q68FD5NM_001288653NM_004859NM_001003908NM_001356393NP_001275582NP_004850NP_001003908NP_001343322Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.

[5][6] Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits.

These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules.

[7] CLTC has been shown to interact with PICALM[8] and HGS.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.