5A1V, 5A1Y1131659042ENSG00000105669ENSMUSG00000055681O14579O89079NM_007263NM_199442NM_199444NM_001330469NM_025088NM_021538NP_001317398NP_009194NP_955474NP_955476NP_067513Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene.

[5][6] The product of this gene is an epsilon subunit of coatomer protein complex.

Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles.

It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Alternatively spliced transcript variants encoding different isoforms have been identified.