3CJW702611819ENSG00000185551ENSMUSG00000030551P24468P43135NM_021005NM_001145155NM_001145156NM_001145157NM_009697NM_183261NP_001138627NP_001138628NP_001138629NP_066285NP_033827NP_899084COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.

[5][6] The COUP acronym stands for chicken ovalbumin upstream promoter.

COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.

[9][10] COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.

Retinoic acid, although not at physiological concentrations, activate this receptor.