[2] This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor.

TRIO is involved in coordinating actin remodeling, which is necessary for cell migration and growth.

They transport their substrates (alpha-tocopherol and phosphatidylinositol or phosphatidylcholine, respectively) between different intracellular membranes.

Family also include a guanine nucleotide exchange factor that may function as an effector of RAC1 small G-protein.

[4] The structure contains several alpha helices as well as a beta sheet composed of 6 strands.