Membranome database provides structural and functional information about more than 6000 single-pass (bitopic) transmembrane proteins from Homo sapiens, Arabidopsis thaliana, Dictyostelium discoideum, Saccharomyces cerevisiae, Escherichia coli and Methanocaldococcus jannaschii.
The database provides information about the individual proteins including computationally generated three-dimensional models of their transmembrane alpha-helices spatially arranged in the membrane, topology, intracellular localizations, amino acid sequences, domain architecture, functional annotation and available experimental structures from the Protein Data Bank.
[1] The second Membranome version[2] provides 3D models of more than 2000 parallel homodimers formed by TM α-helices of bitopic proteins from different organisms which were generated using TMDOCK program.
[4] The database includes downloadable coordinate files of transmembrane helices and their homodimers with calculated membrane boundaries.
[5] The database website provides access to related webservers, FMAP[6] and TMDOCK which have been developed for modeling individual alpha-helices and their dimeric complexes in membranes.