Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord.

IL8RA, IL8RB, which encodes another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.

[6] Blocking CXCR1 (e.g., with repertaxin[7]) inhibits some human breast cancer stem cells (in vitro and in mice).

[8] In malignant melanoma expression of CXCR1 at the cell surface is present, independent of the cancers stage.

[11][12] This article incorporates text from the United States National Library of Medicine, which is in the public domain.