4RUI, 1Z10, 1Z11, 2FDU, 2FDV, 2FDW, 2FDY, 3EBS, 3T3Q, 3T3R, 4EJJ154813087ENSG00000255974ENSMUSG00000005547P11509P20852NM_000762NM_007812NP_000753n/aCytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body.

It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids.

CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

[5] Click on genes, proteins and metabolites below to link to respective articles.

Significant interindividual variability in CYP2A6 apoprotein and mRNA levels has been observed.