[2] The Caddo River flows out of the Ouachita Mountains through Montgomery, Pike, and Clark counties in Arkansas before flowing into DeGray Lake and then to its terminus at the Ouachita River north of Arkadelphia, Arkansas.

The upper Caddo is known as a good family canoeing river and is a popular destination for fishing.

Smallmouth and spotted bass are found in quantity, as are longear and green sunfish.

The lower course of the Caddo, below Degray Dam, is also a popular fishing and canoeing river, although the length of river remaining is only a few miles at that point.

Communities through which the Caddo River passes are: On the night of June 11, 2010, between 200 and 300 campers awoke to rapidly rising water,[4] as a flash flood along the Caddo and Little Missouri Rivers killed twenty people.