[1] Blood calcium levels should be measured when used and extra care should be taken in those with a history of kidney stones.

[2][8] It is closely related to calcium borogluconate, which is commonly used in veterinary medicine owning to its higher solubility.

[2] Though it does not have an effect on potassium levels in the blood, it reduces the excitability of cardiomyocytes, thereby lowering the likelihood of cardiac arrhythmias.

[14] It is also used to counteract an overdose of Epsom salts magnesium sulfate,[15] which is often administered to pregnant women in order to prophylactically prevent seizures (as in a patient experiencing preeclampsia).

Magnesium sulfate is no longer given to pregnant women who are experiencing premature labor in order to slow or stop their contractions (other tocolytics are now used instead due to better efficacy and side effect profiles).

Rapid intravenous injections of calcium gluconate may cause hypercalcemia, which can result in vasodilation, cardiac arrhythmias, decreased blood pressure, and bradycardia.

[19] It is also reported that this form of calcium increases renal plasma flow, urine production, sodium excretion,[20][21] glomerular filtration rate,[22] and prostaglandin E2 and F1-alpha levels.