Via the Maury, the Calfpasture's waters flow into the James River, thence Chesapeake Bay and the Atlantic Ocean.

[1] The Calfpasture River originates on the slopes of Gordons Peak, in Augusta County, near Shenandoah Mountain, in George Washington National Forest.

The tributary Braley Branch joins just before the Calfpasture River flows by the small settlement of West Augusta.

The Calfpasture River flows by the small town of Little Baltimore, after which one of its main tributaries, Hamilton Branch, joins.

The river passes the small town of Marble Valley, then Clayton Mill Creek joins, after which the river leaves Augusta County and enters Rockbridge County.