The southern terminus of SR 269 is at State Route 33 in Avenal, where it drops into the San Joaquin Valley at I-5.

From the Fresno-Kings county line, right before I-5 to its northern terminus at SR 145, the road is known as Lassen Avenue and heads due north through Huron.

The route was defined as a California State route in 1972 as "SR 33 at Avenal to SR 145 near Five Points.”[4] Except where prefixed with a letter, postmiles were measured on the road as it was when the route was established, based on the alignment that existed at the time, and do not necessarily reflect current mileage.

R reflects a realignment in the route since then, M indicates a second realignment, L refers to an overlap due to a correction or change, and T indicates postmiles classified as temporary (for a full list of prefixes, see California postmile § Official postmile definitions).

[5] Segments that remain unconstructed or have been relinquished to local control may be omitted.