Campofranco (Campufrancu in Sicilian) is a municipality (Italian: comune) in the Province of Caltanissetta in the Italian region of Sicily, located about 70 kilometres (43 mi) southeast of Palermo and about 35 km (22 mi) west of Caltanissetta.

Campofranco borders the following municipalities: Aragona, Casteltermini, Grotte, Milena, Sutera.

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