Serradifalco (Sicilian: Serradifarcu) is a town and comune in the province of Caltanissetta, Sicily, Italy.

The town itself was founded in 1640 under permit from King Philip IV of Spain to Maria Ventimiglia, grandmother and governess of Baron Francesco Grifeo, a minor.

In 1652, ownership of the Barony and Town passed to the Lo Faso family.

He was a renowned archaeologist and was instrumental in promulgating the excavation and restoration of the Valley of the Temples in Agrigento.

In the great emigration of Sicilians to the United States in the late 19th and early 20th centuries, many Serradifalchesi farm laborers and sulfur miners went to American towns, including Pittston and Robertsdale, where they worked as coal miners; and to Buffalo and its rural environs, where they found employment with the steel plants and railroads, and in the strawberry and corn fields.