Marianopoli (Sicilian: Manchi) is a comune (municipality) in the Province of Caltanissetta in the Italian region Sicily, located about 80 kilometres (50 miles) southeast of Palermo and about 20 kilometres (12 miles) northwest of Caltanissetta.

Marianopoli borders the following municipalities: Caltanissetta, Mussomeli, Petralia Sottana, Villalba.

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