Mazzarino (Sicilian: Mazzarinu) is a city and comune in the province of Caltanissetta in the region of Sicily, Italy.

The city emerged in the second half of the 13th century.

In 1507, the lords of the manor received the title Count of Mazzarini.

In the 1950s, the local friary was the stage for the highly debated Mazzarino Friars case.

This Sicilian location article is a stub.