Camps quinoline synthesis

The Camps quinoline synthesis (also known as the Camps cyclization) is a chemical reaction whereby an o-acylaminoacetophenone is transformed into two different hydroxyquinolines (products A and B) using hydroxide ion.

[1][2][3][4] The relative proportions of the hydroxyquinolines (A and B) produced are dependent upon the reaction conditions and structure of the starting material.

Although the reaction product is commonly depicted as a quinoline (the enol form), it is believed that the keto form predominates in both the solid state and in solution, making the compound a quinolone.

[5] An example of the Camps reaction is given below:[5] The amides of 1,3-enaminoketones react to form pyridinones-2 under similar conditions.

[6]